Laboratory of Fundamental Chemistry

Preparation of Multihalo-4,7’-bibenzo[b]thiophenes as Novel Molecular Scaffolds

 4,7’-Bibenzo[b]thiophenes bearing chlorine, bromine, iodine, and silicon atoms in one molecule was prepared as novel molecular scaffold. Three different aryl groups were site-selectively introduced by Suzuki-Miyaura cross coupling reactions and a C-H direct arylation while the trialkylsilyl group behaved as a protecting group (a molecular model is shown). Crystal structure of the precursor, (bromo)(chloro)(triisopropylsilyl)bibenzothiophene was analyzed to show directions of the Br—Cl axis and the side chain in the crystal.

Preparation of Multihalo-4,7’-bibenzo[<em>b</em>]thiophenes as Novel Molecular Scaffolds

  1. S. Mikami, A. Matsuo, E. Kwon, K. Toyota
    Synlett, 2021, 32 (18), 1826–1832. DOI: 10.1055/s-0040-1719839.
    URL: Thieme E-Journals - Synlett / Abstract (
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