Laboratory of Organic Reaction Processes

Research Area

• Synthetic Organic Chemistry
• Organometallic Chemistry

Research Subjects

• Development of Highly Stereoselective Asymmetric Reactions Using Organocatalysts
• Development of Organic Transformation Reactions Using Enzyme Mimics as Catalysts
• Development of Novel Synthetic Reactions Using Transition Metal Catalysts
• Highly Efficient and Stereoselective Synthesis of Biologically Active Compounds

Overview of Research

Now a day, the development not only of highly selective reactions leading to desired compounds but also of advanced organic transformations to minimizing the environmental burdens is highly challenging tasks for organic chemists. Our research interests have been focused on the creation of environmentally benign processes using metal complexes and organic compounds as the designed catalyst molecules by taking advantage of the inherent property of these molecules. Furthermore we apply these advanced molecular transformations to selective and efficient synthesis of useful organic materials or biologically active compounds.

Selected Publications

• Asymmetric Direct Vinylogous Aldol Reaction of Furanone Derivatives Catalyzed by an Axially Chiral Guanidine.
  Hitoshi Ube, Naoki Shimada and Masahiro Terada, Angew. Chem., Int. Ed. 2010, 49, 1858-1861.
• Chiral Phosphoric Acid-Governed Anti-Diastereoselective and Enantioselective Hetero-Diels-Alder Reaction of Glyoxylate.
  Norie Momiyama, Hideaki Tabuse and Masahiro Terada, J. Am. Chem. Soc. 2009, 131, 12882-12883.
• Double Bond Isomerization/Enantioselective Aza-Petasis-Ferrier Rearrangement Sequence as an Efficient Entry to Anti- and Enantioenriched β-Amino Aldehydes.
  Masahiro Terada and Yasunori Toda, J. Am. Chem. Soc. 2009, 131, 6354-6355.
• Platinum-Catalyzed Dehydroalkoxylation-Cyclization Cascade via N-O Bond Cleavage.
  Itaru Nakamura, Yusuke Sato and Masahiro Terada, J. Am. Chem. Soc. 2009, 131, 4198-4199.
• Five-Bond Cleavage in Copper-Catalyzed Skeletal Rearrangement of O-Propargyl Arylaldoximes to β-Lactams.
  Itaru Nakamura, Toshiharu Araki and Masahiro Terada, J. Am. Chem. Soc. 2009, 131, 2804-2805.
• Enantioselective Activation of Aldehydes by Chiral Phosphoric Acid Catalysts in an Aza-Ene-Type Reaction between Glyoxylate and Enecarbamate.
  Masahiro Terada, Kazuyo Soga and Norie Momiyama, Angew. Chem., Int. Ed. 2008, 47, 4122-4125.

Contact Information

　“Please delete “/” after “@” in a mail address.”

• Masahiro TERADA
  (TEL +81-22-795-6602, Email: mterada@/m.tohoku.ac.jp)
• Itaru NAKAMURA
  (TEL +81-22-795-6754, Email: itaru-n@/m.tohoku.ac.jp)
• Norie MOMIYAMA
  (TEL +81-22-795-6583, Email: momiyama@/m.tohoku.ac.jp)
• Azusa KONDOH
  (TEL +81-22-795-3898, Email: kondoha@/m.tohoku.ac.jp)

Fax:FAX +81-22-795-6602